Respiratory Science Centre

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External Collaboration

University of Dresden
Klinik- und Poliklinik für Hals-, Nasen-, Ohrenheilkunde

Studies with Dr. Thomas Hummel on the voluntary and involuntary nature of the cough reflex in human volunteers. Using electrophysiological techniques, the neurological nature of cough was explored.

• Pharyngeale Sensitivität bei Husten in Folge einer Infektion der oberen Atemwege. Hummel T, Haenel T, Pauli E, West W, Hull D. Otrohinolaryngol Nova. 2001; 11: 27.

• Assessment of pharyngeal sensitivity to mechanical stimuli using psychophysical and electrophysiological techniques. Hummel T, Haenel T, Hull D. Pulm Pharmacol Ther. 2002; 15:321-332.

University of Hull
Department of Academic Medicine

Studies with Professor Alyn Morice and his team investigated the responses of common cough-reducing medicines in panels of healthy volunteers. The technique of artificially induced cough was used to better understand the magnitude of the metabolism and clinical effects of medicines such as dextromethorphan and codeine.

• The antitussive effect of dextromethorphan in relation to CYP2D6 activity. Abdul Manap,R, Wright CE, Gregory A, Rostami-Hodjegan A, Meller ST, Kelm GR, Lennard MS, Tucker GT, Morice AH. Br J Clin Pharmacol. 1999 Sep;48(3):382-7.

• Optimised delivery of an antitussive improves effectiveness. D. Hull, C. Wright, J. Cronin, D. Dobroszi, S. Hoke, A. Noronha, L. Pavesi, A. Sakhardande, G. Thompson, A. Weeks, A. Wilson, A. Morice. European Resp. Rev. 2002; 12: 85, 270-274.

University of Wales
Common Cold Centre

Clinical testing of new and existing medications for Common Cold and Flu. Various research projects examining test methods and the clinical efficacy of a variety of common cold remedy ingredients.

• Effect of placebo treatment on cough associated with Common Cold. Lee PCL, Jawad MSM, Hull JD., West WHL, Porter K, Eccles R. British Journal of Clinical Pharmacology; 2001; 51; 373.

• The antitussive effect of placebo treatment on cough associated with acute upper respiratory infection. Patrick CL Lee, Mtutaz AM Jawad, J David Hull, Will HL West, Kerry Shaw & Ron Eccles. Psychosomatic Medicine. 2004 (submitted for publication)